Endothelial Gasdermin D Induces Mitochondrial Damage and Activates the STING Pathway in Lipopolysaccharide-Accelerated Atherosclerosis
Our findings elucidate the mechanism by which endothelial GSDMD exerts its atherogenic effects by increasing mitochondrial damage and upregulating the STING pathway in LPS-accelerated atherosclerosis. GSDMD promises to be a critical therapeutic target for atherosclerotic cardiovascular diseases. <i>Antioxid. Redox Signal.</i> 44, 61-84.
Authors
- Shiyao Xie (ORCID: https://orcid.org/0000-0002-7939-1571)
- Hong Jiang (ORCID: https://orcid.org/0000-0002-7260-9646)
- Enyong Su
- Lili S. Wei (ORCID: https://orcid.org/0000-0003-2891-5889)
- Xuelin Cheng (ORCID: https://orcid.org/0000-0002-0288-2794)
- Peng Yu (ORCID: https://orcid.org/0000-0003-4942-7139)
- Junqiang Xue (ORCID: https://orcid.org/0000-0001-5103-4778)
- Ming Liu (ORCID: https://orcid.org/0000-0003-3222-8715)
- Xiaoyue Song
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Shanghai Xuhui Central Hospital (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Antioxidants and Redox Signaling
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1177/15230864251380286
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81