Human Papillomavirus Vaccination Coverage Estimates Among the Primary Target Cohort (9–14-Year-Old Girls) in the World (2010–2024)

<b>Background/Objectives</b>: Monitoring human papillomavirus (HPV) vaccine coverage worldwide can provide valuable insight into cervical cancer prevention. The aim of this manuscript was to assess the HPV vaccination coverage among the primary target cohort (9-14-year-old girls) in the world from 2010 to 2024. <b>Methods</b>: A descriptive epidemiological study (with an ecological study design) was carried out. Trends in HPV vaccination coverage were examined using the joinpoint regression analysis. <b>Results</b>: The HPV vaccination was introduced into the national schedule of 147 countries in 2024. Globally, coverage with the first dose of the HPV vaccine in the primary target cohort (9-14-year-old girls) was estimated at 56.9% in 2024. The growth trend in HPV vaccination coverage was significant mainly in the most developed countries (e.g., such as the USA, Canada and Germany), while trends were 10 times faster in other countries such as Armenia, Indonesia and Tanzania. A decline in trends of HPV vaccination coverage was significant in some developing countries (e.g., such as Panama, Sri Lanka, and Suriname) and in one of the most developed countries-the United Kingdom. <b>Conclusions</b>: A better understanding of changes in HPV vaccination coverage worldwide and further efforts to improve coverage to the target of 90% may contribute to more effective disease prevention.