Effect of a Citicoline-Containing Supplement on Lipid Profile and Redox Status in Healthy Volunteers in Relation to Lifestyle Factors

This study aimed to investigate the effects of a new formulation combining citicoline, vitamin C, and extracts from green tea and aronia (Cytodeox™) on the lipid profile and redox status in healthy individuals following a six-month intervention. Additionally, we examined whether these effects depend on lifestyle factors such as body mass index (BMI), alcohol consumption, smoking and physical activity. Forty-three volunteers aged 40–65 (F31/M12) completed the study. Prior to the intervention, all participants filled out a questionnaire assessing their health status and lifestyle habits. At baseline and after supplementation, anthropometric and physical parameters were measured, and fasting blood samples were collected from all participants. Furthermore, all participants were grouped based on their gender and lifestyle habits. Cytodeox™ significantly reduced lipid profile parameters and malondialdehyde (MDA) levels in the overall group. The analysis of these effects in relation to lifestyle habits revealed that smoking, but not alcohol consumption, negatively influences the effects of the supplement. Surprisingly, the beneficial effects were observed in the overweight group and those leading a sedentary lifestyle. The results strongly suggest that six months of supplementation with Cytodeox™ can improve the lipid profile and redox status, even in individuals with some poor lifestyle habits.