Protective effect and mechanism of Saikosaponin A against oxidative damage in cochlear hair cells <i>in vitro</i>

SSA alleviates GO-induced oxidative stress and apoptosis in HEI-OC1 cells by activating the KEAP1/NFE2 signaling pathway. These findings support the potential application of SSA in protecting cochlear hair cells from oxidative damage, warranting further <i>in vivo</i> investigation.

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Publication Details

Journal
Nutritional Neuroscience
Published
2025-09-29
DOI
https://doi.org/10.1080/1028415x.2025.2559872
Primary Topic
Natural product bioactivities and synthesis
Type
article
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article

Protective effect and mechanism of Saikosaponin A against oxidative damage in cochlear hair cells in vitro

Kaifeng Dong, Guangli Wu, Haolei Zhang
Nutritional Neuroscience
Natural product bioactivities and synthesis
article

Protective effect and mechanism of Saikosaponin A against oxidative damage in cochlear hair cells in vitro

Kaifeng Dong, Guangli Wu, Haolei Zhang
article en

Abstract

SSA alleviates GO-induced oxidative stress and apoptosis in HEI-OC1 cells by activating the KEAP1/NFE2 signaling pathway. These findings support the potential application of SSA in protecting cochlear hair cells from oxidative damage, warranting further <i>in vivo</i> investigation.

Nutritional NeuroscienceVol. 29(2)
First Affiliated Hospital of Hebei Medical University (CN)
Openalex Percentile: Top 76%
Natural product bioactivities and synthesis
DOISourceOpenAlex
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Protective effect and mechanism of Saikosaponin A against oxidative damage in cochlear hair cells <i>in vitro</i> — Kaifeng Dong, Guangli Wu, et al. · Nutritional Neuroscience (2025) | TGRS Research Map | TGRS