Clinically Relevant Patterns of Co‐Fluctuating Structure and Function in Multiple Sclerosis
Our multimodal MRI approach revealed co-fluctuating regional patterns of lesions, structural disconnection, and functional hyperconnectivity in MS, offering a more comprehensive explanation of clinical outcomes than traditional MRI metrics.
Authors
- Marzia Mortilla (ORCID: https://orcid.org/0000-0003-4978-6537)
- Nicola De Stefano (ORCID: https://orcid.org/0000-0003-0728-5259)
- Rosa Cortese (ORCID: https://orcid.org/0000-0002-9803-7914)
- Marco Battaglini (ORCID: https://orcid.org/0000-0002-9188-4408)
- Emilio Portaccio (ORCID: https://orcid.org/0000-0002-9662-1762)
- Maria Laura Stromillo
- Ludovico Luchetti
- Menno Michiel Schoonheim (ORCID: https://orcid.org/0000-0002-2504-6959)
- Giordano Gentile (ORCID: https://orcid.org/0000-0002-8481-2801)
- Jian Zhang (ORCID: https://orcid.org/0000-0001-8820-3248)
- Maria Pia Amato
Institutions
- University of Siena (IT)
- Amsterdam Neuroscience (NL)
- Meyer Children's Hospital (IT)
- Don Carlo Gnocchi Foundation (IT)
- Siena Biotech (Italy) (IT)
- University of Florence (IT)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1111/ene.70367
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Bristol-Myers Squibb
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- Celgene
- Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques
- Atara Biotherapeutics
- ZonMw
- MedDay Pharmaceuticals
- Amsterdam Neuroscience
- Eurostars