Antibacterial cyclopentenones from the coprophilous fungus <i>Clonostachys pseudochroleuca</i>

The chemical study of the ethyl acetate soluble fraction from the ethyl acetate:methanol (1:1) extract of the culture of <i>Clonostachys pseudochroleuca</i> led to the isolation of a new cyclopentenone, (4<i>S</i>,5<i>R</i>) 4-benzoyl-3,4,5-trihydroxy-2-(4-hydroxyphenyl)cyclopent-2-en-1-one (<b>2</b>), along with the known phaseocyclopentenone A (<b>1</b>). Their structures were assigned on the basis of 1D and 2D NMR spectroscopy and HRESIMS data. The absolute configuration of the chiral centres was determined by Electronic Circular Dichroism (ECD) analysis. In the microdilution assay, the crude extract exhibited weak activity against <i>Escherichia coli</i> AG100 and <i>Klebsiella pneumoniae</i> 55 with MIC values of 256 µg/mL and 512 µg/mL, respectively. Compound <b>1</b> showed moderate activity against <i>E. coli</i> AG100 with an MIC of 64 µg/mL, while the new metabolite <b>2</b> exhibited moderate activity against <i>Klebsiella pneumoniae</i> ATCC11 with an MIC of 64 µg/mL.

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Publication Details

Journal
Natural Product Research
Published
2025-09-29
DOI
https://doi.org/10.1080/14786419.2025.2565818
Primary Topic
Plant Pathogens and Fungal Diseases
Type
article
Field-Weighted Citation Impact
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article

Antibacterial cyclopentenones from the coprophilous fungus Clonostachys pseudochroleuca

Joseph Tchamgoue, Bienvenu Tsakem, Léon Azefack Tapondjou, Rémy Bertrand Teponno et al.
Natural Product Research
Plant Pathogens and Fungal Diseases
article

Antibacterial cyclopentenones from the coprophilous fungus Clonostachys pseudochroleuca

Joseph Tchamgoue, Bienvenu Tsakem, Léon Azefack Tapondjou, Rémy Bertrand Teponno, Victor Kuete, Rainer Kalscheuer, André-Ledoux Njouonkou, Beaudelaire Kemvoufo Ponou, Jenifer R. N. Kuete, Paul Eckhardt, Siméon F. Kouam, Till Opatz, Annick B. F. Kapche, Aron Trucksess
article en

Abstract

The chemical study of the ethyl acetate soluble fraction from the ethyl acetate:methanol (1:1) extract of the culture of <i>Clonostachys pseudochroleuca</i> led to the isolation of a new cyclopentenone, (4<i>S</i>,5<i>R</i>) 4-benzoyl-3,4,5-trihydroxy-2-(4-hydroxyphenyl)cyclopent-2-en-1-one (<b>2</b>), along with the known phaseocyclopentenone A (<b>1</b>). Their structures were assigned on the basis of 1D and 2D NMR spectroscopy and HRESIMS data. The absolute configuration of the chiral centres was determined by Electronic Circular Dichroism (ECD) analysis. In the microdilution assay, the crude extract exhibited weak activity against <i>Escherichia coli</i> AG100 and <i>Klebsiella pneumoniae</i> 55 with MIC values of 256 µg/mL and 512 µg/mL, respectively. Compound <b>1</b> showed moderate activity against <i>E. coli</i> AG100 with an MIC of 64 µg/mL, while the new metabolite <b>2</b> exhibited moderate activity against <i>Klebsiella pneumoniae</i> ATCC11 with an MIC of 64 µg/mL.

Natural Product Research
Université de Yaoundé I (CM), Université de Dschang (CM), Johannes Gutenberg University Mainz (DE), University of Bamenda (CM), Sefako Makgatho Health Sciences University (ZA), Heinrich Heine University Düsseldorf (DE)
Openalex Percentile: Top 72%
Plant Pathogens and Fungal Diseases
DOISourceOpenAlex
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