Single-cell and bulk RNA-sequencing reveal PRRX2-driven cancer-associated fibroblast-mediated perineural invasion for predicting the immunotherapy outcome in colorectal cancer
This analysis established PRRX2-driven MMP2+myCAFs as pivotal mediators of CRC perineural invasion through TGF-β/ECM remodeling. The PRRX2 score serves as a biomarker for prognosis prediction and immunotherapy outcome.
Authors
- Wenqi Bai (ORCID: https://orcid.org/0009-0003-9421-2513)
- Kaili Cui (ORCID: https://orcid.org/0000-0002-1866-4783)
- Xu Zhou (ORCID: https://orcid.org/0000-0002-2556-6479)
- M. Chen (ORCID: https://orcid.org/0009-0006-2973-7913)
- Bo Li (ORCID: https://orcid.org/0000-0001-9944-0003)
- Feng Li (ORCID: https://orcid.org/0000-0002-6707-9484)
- Feng Han (ORCID: https://orcid.org/0000-0003-0985-980X)
- Yue Cai (ORCID: https://orcid.org/0000-0002-4970-9673)
Institutions
- Shanxi Medical University (CN)
- Shanxi Provincial Cancer Hospital (CN)
- Cancer Hospital of Chinese Academy of Medical Sciences (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.3389/fcell.2025.1620388
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09