Effect of sodium imbalance and seizure on hippocampal damage in rats
Hyponatremia, particularly in its chronic form, exacerbates seizure-induced hippocampal injury, reflected by reduced BDNF expression and severe ultrastructural damage. These findings provide novel preclinical evidence linking sodium imbalance to hippocampal vulnerability and highlight the need for further mechanistic and translational studies.
Authors
- Beril Dilber (ORCID: https://orcid.org/0000-0002-7633-0060)
- Ali Cansu (ORCID: https://orcid.org/0000-0002-1930-6312)
- Seren Gülşen Gürgen (ORCID: https://orcid.org/0000-0002-5514-1404)
- Özgül Balcı (ORCID: https://orcid.org/0000-0001-5974-4387)
Institutions
- Karadeniz Technical University (TR)
- Manisa Celal Bayar University (TR)
Publication Details
- Journal
- Neurological Research
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1080/01616412.2025.2566229
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00