Tuning polyaniline doped with poly(4-styrenesulfonic acid) (PANI : PSS) as a nano-drug carrier for insulin delivery
Polyaniline (PANI) is one of the most well-known conductive polymers, but it is not soluble in water. PSS, a polyelectrolyte and dopant, has demonstrated the ability to enhance both electrical conductivity and solubility in water. PANI : PSS were synthesized under the effect of polymerization times, oxidant (APS) ratios, and dopant (PSS) ratios. The suitable synthesized PANI : PSS was the ANI : APS mole ratio of 1 : 1 and ANI : PSS wt ratio of 1 : 5 for 24 h providing the highest electrical conductivity (6.84 x 10<sup>-2</sup> ± 4.30 x 10<sup>-4</sup> S cm<sup>-1</sup>) and still remained as nanoparticles (42.11 ± 7.41 nm). Insulin, a model drug, was ion-exchanged with PANI : PSS, replacing PSS. The amount of insulin loaded into PANI : PSS (insulin-PANI : PSS) was varied with weight ratios of 0.5 : 1, 1 : 1, and 3 : 1, with the 1 : 1 wt ratio exhibiting 96.4% loading efficiency. The synthesized PANI : PSS is demonstrated as a potential insulin carrier for transdermal drug delivery.
Authors
- Phimchanok Sakunpongpitiporn
- Rawita Morarad
- Anuvat Sirivat (ORCID: https://orcid.org/0000-0002-4798-9325)
- Nophawan Paradee (ORCID: https://orcid.org/0000-0002-9976-5825)
- Walaiporn Prissanaroon‐Ouajai
- Kornkanok Rotjanasuworapong
Institutions
- Chulalongkorn University (TH)
- Mahanakorn University of Technology (TH)
- King Mongkut's University of Technology Thonburi (TH)
- King Mongkut's University of Technology North Bangkok (TH)
Publication Details
- Journal
- RSC Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ra04956c
- Citations
- 2
- Primary Topic
- Conducting polymers and applications
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- Chulalongkorn University
- National Research Council of Thailand
- Thailand Science Research and Innovation