Features of IL-8 and IL-10 production in pregnant women with urogenital infections

Objective. To determine features of IL-8 and IL-10 production in pregnant women with urogenital infections (UGI) in the first trimester, and their role for prognosis of obstetric and perinatal complications. Materials and methods . The prospective cohort study included 98 pregnant women in the first trimester, of which 66 patients were diagnosed with genital infections (GI) — main group, 8 had genital infections combined with urinary tract infection — comparison group, and 24 pregnant women without urogenital infection formed the control group. Concentration of IL-8 and IL-10 in the blood serum was determined by the enzyme immunoassay method. The characteristics of the course of pregnancy, childbirth, and the condition of the newborns were assessed. Results . Systemic production of IL-8 and IL-10 in the first trimester of pregnancy does not depend on the presence of genital infection. Recurrence in patients of the main group is preceded by higher serum levels of IL-8, determined in pregnant women in the first trimester with diagnosed GI (p=0.0001; Z=3.794). It is possible to predict the development of a relapse of GI in the second-third trimester (AUC=0.809; 95 % CI 0.694-0.895; p=0.0001) at IL-8 concentration of more than 7.6 pg/ml in pregnant women with GI in the first trimester with a sensitivity of 82.4% and a specificity of 83.7%. The formation of placental insufficiency in patients of the main and control groups was preceded by higher concentrations of IL-8 in the first trimester of pregnancy (pо = 0.0001; Z=3.871; pк =0.025; Z=2.235). In pregnant women without UGI with a serum IL-8 level of more than 14.15 pg/ml, it is possible to predict the development of placental insufficiency with a sensitivity of 100% and a specificity of 95.5% (AUC=0.977; 95% CI 0.817-0.988; p=0.0001). Development of threatened miscarriage was associated with higher serum levels of IL-10 in the first trimester of pregnancy (pо=0.007; Z=2.682; pк =0.031; Z= 2.153) in the main and control groups. Conclusion. Determination of IL-8 and IL-10 levels in the blood serum of women in the first trimester of pregnancy allows predicting the development of gestational complications such as threatened miscarriage, development of genital infection and placental insufficiency, development of genital infection and placental insufficiency, timely formation of risk groups for medical prevention of these complications and, thereby, improvement of maternal and perinatal outcomes.