Identification and Characterization of Three Novel Biomarkers for Mixed/Cholestatic Drug‐Induced Liver Injury

We identified novel DILI biomarkers that can be used to clinically assess patients with mixed/cholestatic DILI and to differentiate these patients from recovered patients and those with other liver diseases.

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Publication Details

Journal
Hepatology Research
Published
2025-09-29
DOI
https://doi.org/10.1111/hepr.70043
Primary Topic
Drug-Induced Hepatotoxicity and Protection
Type
article
Field-Weighted Citation Impact
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Identification and Characterization of Three Novel Biomarkers for Mixed/Cholestatic Drug‐Induced Liver Injury

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Hepatology Research
Drug-Induced Hepatotoxicity and Protection
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Identification and Characterization of Three Novel Biomarkers for Mixed/Cholestatic Drug‐Induced Liver Injury

Naoya Sakamoto, Keiji Tsuji, Yoshiro Saito, Kazuhide Takata, Kosuke Saito, Motonobu Sato, Kazuhiko Mori, Hajime Takikawa, Ruri Kikura‐Hanajiri, Noriaki Arakawa, Ken Sato, Takayoshi Nishiya, Mitsuhiko Aiso, Kazuhiko Takamatsu, Tatehiro Kagawa, Shunji Hirose, Toshio Uraoka, Shotaro Sakisaka, Koji Ogawa, Takashi Izumi, Nami Mori, Yasuo Ohno, Yuji Kumagai
article en

Abstract

We identified novel DILI biomarkers that can be used to clinically assess patients with mixed/cholestatic DILI and to differentiate these patients from recovered patients and those with other liver diseases.

Hepatology ResearchVol. 56(1)
Kihara Institute for Biological Research (JP), Tokai University (JP), Astellas Pharma (Japan) (JP), Teikyo University of Science (JP), Gunma University (JP), Daiichi Sankyo (Germany) (DE), Hokkaido University (JP), Fukuoka University (JP), Daiichi-Sankyo (Japan) (JP), Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital (JP), National Institute of Occupational Safety and Health (JP), Memorial Foundation (US), National Institute of Health Sciences (JP), Kitasato Institute Hospital (JP), Teikyo University (JP)
Openalex Percentile: Top 65%
Drug-Induced Hepatotoxicity and Protection
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