Distinct patterns of genetic overlap among multimorbidities revealed with trivariate MiXeR
Overall, trivariate MiXeR offers a novel and efficient tool for investigating patterns of genetic overlap among three complex phenotypes. This contributes to a better understanding of genetic relationships between complex traits and disorders, potentially providing new insights into the mechanisms underlying common multimorbidities. Trivariate MiXeR is freely available at https://github.com/precimed/mix3r .
Authors
- Markos Tesfaye (ORCID: https://orcid.org/0000-0002-3351-701X)
- Olav B. Smeland (ORCID: https://orcid.org/0000-0002-3761-5215)
- Piotr Jahołkowski (ORCID: https://orcid.org/0000-0001-9408-3107)
- Vera Fominykh (ORCID: https://orcid.org/0000-0001-5490-2390)
- Espen Hagen (ORCID: https://orcid.org/0000-0002-1321-5970)
- Alexey A. Shadrin (ORCID: https://orcid.org/0000-0002-7467-250X)
- Srdjan Djurovic (ORCID: https://orcid.org/0000-0002-8140-8061)
- Dennis van der Meer (ORCID: https://orcid.org/0000-0002-0466-386X)
- Guy Hindley (ORCID: https://orcid.org/0000-0003-1666-4701)
- Gleda Kutrolli (ORCID: https://orcid.org/0000-0001-6602-2622)
- Nadine Parker (ORCID: https://orcid.org/0000-0002-8369-0152)
- Kevin S. O’Connell (ORCID: https://orcid.org/0000-0002-6865-8795)
- Oleksandr Frei (ORCID: https://orcid.org/0000-0002-6427-2625)
- Zillur Rahman (ORCID: https://orcid.org/0000-0003-2785-0200)
- Anders M. Dale
- Ole A. Andreassen
Institutions
- Oslo University Hospital (NO)
- J. Craig Venter Institute (US)
- King's College London (GB)
- University of Oslo (NO)
- University of California System (US)
- Maastricht University (NL)
- University of California San Diego (US)
- University of Bergen (NO)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s13073-025-01528-3
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- European Commission
- Universitetet i Oslo
- Norges Forskningsråd
- National Institutes of Health
- Helse Sør-Øst RHF