Single-cell RNA sequencing reveals NFATc1-mediated regulatory mechanisms of vascular smooth muscle cell osteogenic transformation in the osteosarcoma microenvironment
At single-cell resolution, NFATc1 marks a VSMC fraction with osteogenic features in osteosarcoma. The associated network suggests testable links to metabolism and matrix remodeling; functional perturbation will be required to establish causality.
Authors
- Shanji Fu
- Dehui Qian (ORCID: https://orcid.org/0000-0003-4297-2919)
- Chunliang Zhang (ORCID: https://orcid.org/0000-0002-4382-2413)
- Huan Feng (ORCID: https://orcid.org/0000-0002-1719-2913)
- X. Yi (ORCID: https://orcid.org/0000-0003-1260-1367)
- T. C. Zhao (ORCID: https://orcid.org/0000-0002-4624-7186)
Institutions
- Army Medical University (CN)
- Chongqing University (CN)
- Xinqiao Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1007/s12672-025-03606-9
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Army Medical University
- Centre Scientifique et Technique du Bâtiment