The impact of tetracosactide on epidural fibrosis in a rat laminectomy model

AIM: Epidural fibrosis is a prevalent and undesirable outcome following spinal surgeries, often leading to recurrent lumbago and radiculopathy that can significantly degrade the quality of life.The current study was designed to explore the potential antifibrotic effects of tetracosactide, a hormonal peptide, within the context of a rat laminectomy model. Z AMA:Epidural fibrozis, spinal cerrahileri takiben grlen yaygn ve istenmeyen bir sonutur ve sklkla yaam kalitesini nemli lde drebilen tekrarlayan lumbago ve radiklopatiye yol aar.Bu alma, hormonal bir peptid olan tetrakosaktidin potansiyel antifibrotik etkilerini bir rat laminektomi modelinde aratrmak zere tasarlanmtr. GERE ve YNTEMLER:almada ratlar gruba ayrlmt: kontrol, lokal tetrakosaktid ve sistemik tetrakosaktid (n=6, grup bana).Kontrol grubuna basit bir laminektomi prosedr uyguland.Lokal tetrakosaktid grubuna ila dorudan dura zerine uygulanmtr