Infant CD4 T-Cell Response to SARS-CoV-2 mRNA Vaccination Is Restricted in Cytokine Production and Modified by Vaccine Manufacturer
These data suggest that infants have restricted induction of cytokine-producing CD4 T-cells following SARS-CoV-2 mRNA vaccination relative to adults.
Authors
- Helen Y. Chu (ORCID: https://orcid.org/0000-0001-8502-9600)
- Alisa Kachikis (ORCID: https://orcid.org/0000-0003-0358-5107)
- Amber Young (ORCID: https://orcid.org/0000-0003-0284-0006)
- MP Peters (ORCID: https://orcid.org/0000-0001-9832-3219)
- Jennifer K. Logue (ORCID: https://orcid.org/0000-0002-7889-8960)
- Jennifer E Stolarczuk (ORCID: https://orcid.org/0009-0008-6708-8170)
- Erik D. Layton (ORCID: https://orcid.org/0000-0001-6409-290X)
- Janet A. Englund (ORCID: https://orcid.org/0000-0003-1134-4178)
- Chetan Seshadri (ORCID: https://orcid.org/0000-0003-2783-7540)
- Whitney E. Harrington (ORCID: https://orcid.org/0000-0002-0121-978X)
- D. Noah Sather (ORCID: https://orcid.org/0000-0002-9128-172X)
- Madeline Glad
- Nana K Minkah
Institutions
- Center for Infectious Disease Research (US)
- Seattle Children's Hospital (US)
- Infectious Disease Research Institute (US)
- University of Washington (US)
- Society for Maternal-Fetal Medicine (US)
- Seattle Children's Hospital (US)
- Seattle Institute for Biomedical and Clinical Research (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1093/ofid/ofaf599
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- University of Washington
- Seattle Children's Research Institute
- Children’s Hospital of Wisconsin Research Institute
- Moderna
- Shionogi
- Seqirus
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- National Center for Advancing Translational Sciences