PREVALENCE OF VARIOUS ETIOPATHOGENIC VARIANTS OF CHRONIC DIFFUSE LIVER DISEASES

Chronic diffuse liver diseases (CDLD) is a collective concept that unites diseases of various etiologies, accompanied by the development of diffuse damage to the liver parenchyma, which is characterized by deviations from the norm in biochemical markers of liver function and lasts more than 6 months. In recent decades, CDPD has been the subject of active study by hepatologists and close attention from practicing physicians. First of all, this is due to the fact that the prevalence of liver diseases is increasing every year all over the world, and most often this pathology develops in people of working age, significantly reducing their quality of life. Data from modern literature indicate that currently chronic liver diseases occupy a significant place among the causes of early disability and mortality of the population. On average, there are more than 2 billion people worldwide suffering from chronic diffuse liver disease (CDLD), which is 100 times higher than the prevalence of HIV infection. In this case, the main contingent of patients becomes, as a rule, the able-bodied, socially active part of the population. CDPD include a wide range of nosologically independent inflammatory diseases of various etiologies Thus, liver lesions of various etiologies occur in approximately the same sequence, called the “liver continuum”, the final link of which is HCC. Therefore, not only effective therapy and measures to prevent the development of CDPD themselves, but also the ability to productively intervene in this continuum are currently one of the most pressing problems of modern hepatology. Given the paucity of epidemiological data from regions of Asia, Africa and Latin America, and the lack of consistency in regional and age-specific patterns of prevalence of chronic diffuse liver disease, further research is required to identify the global burden of the disease. The purpose of this review was to search for literature data on the prevalence of diffuse infiltrative and inflammatory liver diseases of various etiopathogenesis. To achieve this goal, publications of foreign authors in the Scopus and Pubmed databases were analyzed. Taking into account the depth of the search - the last 10 years, the language of publication - Russian, English, 38 full-text articles were included in the analysis