Targeting c‐Myc enhances immunotherapy efficacy in combination with Ras inhibitor in triple‐negative breast cancer
In summary, our investigation identifies a molecular vulnerability in c-Myc-driven TNBC, where Ras inhibition reinforces c-Myc-targeted therapy and potentiates immune checkpoint blockade, presenting a promising strategy to improve immunotherapy efficacy in TNBC.
Authors
- Yaqin Shi
- Yuhan Zhao (ORCID: https://orcid.org/0000-0001-5529-1907)
- Fangyan Gao
- Xiaojie Liang (ORCID: https://orcid.org/0000-0002-1702-8849)
- Ye Zhu
- Fan Ye
- Yiqiu Liu (ORCID: https://orcid.org/0000-0002-7575-1533)
- Xiaoxiang Guan (ORCID: https://orcid.org/0000-0003-3382-7808)
Institutions
- Soochow University (CN)
- Jiangsu Cancer Hospital (CN)
- Jiangsu Province Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1002/ctm2.70484
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00