Inflammation in Cerebral Cavernous Malformations: Differences Between Malformation Related Epilepsy vs. Symptomatic Hemorrhage
Inflammatory processes in CCMs seem to be driven by broad and multiple pathways because both COX-2 and NLRP3-driven inflammatory pathways are consistently activated. As a novelty, this study showed that patients with symptomatic hemorrhage showed upregulated inflammatory enzyme activity compared to patients with CCM-related epilepsy. No direct links between NLRP3, COX-2 expression, and radiological, pathological, or preexisting patient conditions were found.
Authors
- Ramazan Jabbarli (ORCID: https://orcid.org/0000-0002-8356-6629)
- Karsten H. Wrede (ORCID: https://orcid.org/0000-0001-7076-3503)
- Börge Schmidt (ORCID: https://orcid.org/0000-0001-6948-7273)
- Jan Rodemerk (ORCID: https://orcid.org/0000-0002-3185-2391)
- Cornelius Deuschl (ORCID: https://orcid.org/0000-0001-9262-7289)
- Philipp Dammann (ORCID: https://orcid.org/0000-0003-3618-5150)
- Ulrich Sure (ORCID: https://orcid.org/0000-0002-9073-1821)
- Alejandro N. Santos (ORCID: https://orcid.org/0000-0002-6616-5313)
- Andreas Junker (ORCID: https://orcid.org/0000-0002-8063-9765)
- Marvin Darkwah Oppong (ORCID: https://orcid.org/0000-0003-1021-5024)
- Michael Forsting (ORCID: https://orcid.org/0000-0002-5584-9824)
- Laurèl Rauschenbach (ORCID: https://orcid.org/0000-0001-8348-4298)
- Yuan Zhu (ORCID: https://orcid.org/0000-0002-5908-0768)
- A. Engel (ORCID: https://orcid.org/0000-0001-6328-2066)
- Julius L. H. Horstmann
Institutions
- Institut für Medizinische Informatik, Biometrie und Epidemiologie (DE)
- Essen University Hospital (DE)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- Cells
- Published
- 2025-09-27
- DOI
- https://doi.org/10.3390/cells14191510
- Primary Topic
- Vascular Malformations Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00