Inhibition of P2X7R Activation Ameliorates Damage to the Corneas and Corneal Nerves of Rats with Streptozotocin (STZ)-Induced Type 1 Diabetes
The increase of P2X7R expression of diabetic rats was not synchronized with the gradually aggravated corneal injure. Inhibition of P2X7R activation can alleviate diabetes-associated corneal injury, regulate the expression of related neurotrophic factors and neuropeptides, and improve the corneal subbasal nerve plexus.
Authors
- Wanting Li
- Shaozhen Zhao
- Qi Li (ORCID: https://orcid.org/0000-0001-8776-8730)
- Wanjun Guo (ORCID: https://orcid.org/0000-0002-3915-5347)
- Yuanyuan Qi
- Qian Guo (ORCID: https://orcid.org/0009-0001-2317-8720)
Institutions
- Sussex Eye Hospital (GB)
- Tianjin Medical University Eye Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Current Eye Research
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1080/02713683.2025.2563129
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00