Multiomic Mendelian randomization analysis of metabolic gene methylation expression and protein levels in lung adenocarcinoma

This multi-omic Mendelian randomization study provides compelling evidence of the role of metabolic genes in LUAD risk. Methylation changes in CHRNA3, altered expression of FLOT1 and HYKK, and protective protein levels of POGLUT3 represent key molecular features associated with disease susceptibility. These findings offer valuable insights into potential molecular targets for early LUAD detection and therapeutic strategies.