Skeletal Muscle Biomarkers of Amyotrophic Lateral Sclerosis: A Large‐Scale, Multi‐Cohort Proteomic Study
We identified an array of novel biomarkers with the potential to serve as response biomarkers to aid therapy development, as well as to shed light on the underlying biology of disease. ANN NEUROL 2026;99:393-407.
Authors
- Ludivine Flotte
- Lucie Bruijn
- Lori L. Jennings (ORCID: https://orcid.org/0000-0001-5130-8417)
- Matthew Nash (ORCID: https://orcid.org/0000-0002-3985-3989)
- Joanne Wuu (ORCID: https://orcid.org/0009-0005-9643-9855)
- Volkan Granit (ORCID: https://orcid.org/0000-0002-6519-7225)
- Sophie Brachat (ORCID: https://orcid.org/0000-0002-3398-8225)
- Michael Benatar (ORCID: https://orcid.org/0000-0003-4241-5135)
- James D. Berry (ORCID: https://orcid.org/0000-0003-0898-6081)
- Magdalena Koziczak‐Holbro
- Michael Bidinosti
- Rahul Sachdev (ORCID: https://orcid.org/0000-0003-2732-5617)
- Anne Cooley (ORCID: https://orcid.org/0009-0002-9449-3848)
- Andrea Malaspina (ORCID: https://orcid.org/0000-0002-8020-7567)
- Jessica Hernandez (ORCID: https://orcid.org/0000-0002-2436-7689)
- Lili Yu (ORCID: https://orcid.org/0000-0002-2427-5784)
- Oleksandr Dergai
Institutions
- Novartis (Switzerland) (CH)
- University of Miami (US)
- Queen Mary University of London (GB)
- Massachusetts General Hospital (US)
- Novartis (China) (CN)
- Novartis (United Kingdom) (GB)
- University College London (GB)
- Novartis Foundation (CH)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1002/ana.78046
- Citations
- 2
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78