Amyloid beta and tau are associated with the dual effect of neuroinflammation on neurodegeneration
Two waves of detrimental neuroinflammation effects on brain density associated with Aβ or tau. Aβ associated with deleterious effect of neuroinflammation on brain density in early AD. Tau associated with deleterious effect of neuroinflammation on brain density in late AD. Interactions of Aβ, tau, and neuroinflammation are associated with cognitive decline.
Authors
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- João Pedro Ferrari‐Souza (ORCID: https://orcid.org/0000-0003-2183-1551)
- Joseph Therriault (ORCID: https://orcid.org/0000-0002-7826-4781)
- Guilherme Povala (ORCID: https://orcid.org/0000-0002-2023-6569)
- Douglas Teixeira Leffa (ORCID: https://orcid.org/0000-0002-4890-8451)
- Eduardo Rigon Zimmer (ORCID: https://orcid.org/0000-0002-5349-0053)
- Miloš D. Ikonomović (ORCID: https://orcid.org/0000-0002-8745-3293)
- Carolina Soares (ORCID: https://orcid.org/0000-0002-2338-4495)
- Guilherme Bauer‐Negrini (ORCID: https://orcid.org/0000-0003-0956-557X)
- Nesrine Rahmouni (ORCID: https://orcid.org/0009-0004-3081-8468)
- Marco Antônio De Bastiani (ORCID: https://orcid.org/0000-0003-3924-5278)
- Pâmela C.L. Ferreira (ORCID: https://orcid.org/0000-0003-2134-9829)
- Andréa Lessa Benedet (ORCID: https://orcid.org/0000-0001-8219-1741)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Stijn Servaes (ORCID: https://orcid.org/0000-0002-4431-957X)
- Bruno Zatt (ORCID: https://orcid.org/0000-0002-8045-957X)
- Victor L. Villemagne (ORCID: https://orcid.org/0000-0002-5832-9875)
- Bruna Bellaver (ORCID: https://orcid.org/0000-0002-2212-3373)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Cristiano Schaffer Aguzzoli (ORCID: https://orcid.org/0000-0002-7378-3830)
- Cécile Tissot (ORCID: https://orcid.org/0000-0003-2711-3833)
- Hussein Zalzale
- Andréia Silva da Rocha (ORCID: https://orcid.org/0000-0003-1567-3374)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Serge Gauthier
- Jenna Stevenson (ORCID: https://orcid.org/0000-0003-2848-1451)
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade Federal de Pelotas (BR)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Douglas Mental Health University Institute (CA)
- Instituto do Cérebro (BR)
- Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean (CA)
- Geriatric Research Education and Clinical Center (US)
- Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal (CA)
- Global Brain Health Institute (US)
- McGill University (CA)
- The University of Texas Southwestern Medical Center (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1002/alz.70746
- Citations
- 7
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.15