A new H <sub>2</sub> Se-selective fluorescent probe based on nitro reduction
Hydrogen selenide (H<sub>2</sub>Se) is an emerging bioactive molecule associated with several physiological and pathological processes. To clarify the effects of H<sub>2</sub>Se in biological systems, the development of highly selective H<sub>2</sub>Se detection tools is essential. Herein, we rationally designed a series of potential H<sub>2</sub>Se probes based on nitroaromatic reduction followed by a self-immolative process and discovered a new H<sub>2</sub>Se detection platform (Nap-NO2-mCl). Nap-NO2-mCl exhibited high selectivity and sensitivity for H<sub>2</sub>Se, making it an effective tool for monitoring triggered-release H<sub>2</sub>Se and exogenous H<sub>2</sub>Se in living cells.
Authors
- Liyue Wang
- Wenfang Liang (ORCID: https://orcid.org/0000-0001-6451-8915)
- Zhongyang Yu (ORCID: https://orcid.org/0000-0001-9148-0895)
- Yalun Dong
- Wanxue Xu (ORCID: https://orcid.org/0000-0003-4720-2841)
- Long Yi (ORCID: https://orcid.org/0000-0001-9641-7131)
- Lu Sun (ORCID: https://orcid.org/0000-0002-1695-3872)
Institutions
- Tianjin Medical University General Hospital (CN)
- Theranostics (New Zealand) (NZ)
- Tianjin Medical University (CN)
- Beijing University of Chemical Technology (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob01386k
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00