Therapeutic Potential of Quercetin, Silibinin, and Crocetin in a High-Fat Diet-Induced Mouse Model of MASLD: The Role of CD36 and PLIN3
Quercetin, silibinin, and crocetin mitigate MASLD progression by reducing steatohepatitis. These effects are associated with distinct modulations of CD36 and PLIN3 protein expression, suggesting that these pathways are promising therapeutic targets in MASLD management. Natural compounds offer a multi-targeted hepatoprotective approach warranting further clinical investigation.
Authors
- Ioannis Katsaros (ORCID: https://orcid.org/0000-0002-6743-8942)
- Nikolaos Kostomitsopoulos (ORCID: https://orcid.org/0000-0003-4787-5106)
- Michail Vailas (ORCID: https://orcid.org/0000-0002-7357-6532)
- Alexandra Giatromanolaki (ORCID: https://orcid.org/0000-0003-3706-8845)
- Alexandra Tsaroucha (ORCID: https://orcid.org/0000-0002-8610-338X)
- Paraskevi Papakyriakopoulou (ORCID: https://orcid.org/0000-0003-0566-0713)
- Dimitriοs Schizas (ORCID: https://orcid.org/0000-0002-7046-0112)
- Georgia Valsami (ORCID: https://orcid.org/0000-0002-2395-6844)
- Fotini Papachristou (ORCID: https://orcid.org/0000-0002-6109-9185)
- Maria Sotiropoulou (ORCID: https://orcid.org/0000-0002-5628-137X)
Institutions
- Democritus University of Thrace (GR)
- National and Kapodistrian University of Athens (GR)
- Biomedical Research Foundation of the Academy of Athens (GR)
- Laiko General Hospital of Athens (GR)
- University Hospital of Alexandroupolis (GR)
Publication Details
- Journal
- Life
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3390/life15101523
- Primary Topic
- Saffron Plant Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00