Predictor Role of VKORC1 rs9923231, CYP4F2 rs2108622, and GGCX rs11676382 Polymorphisms of 5 Years Mortality of Patients with Acute Ischemic Stroke

<i>Background and Objectives</i>: The aim of this study was to evaluate the potential predictive value of <i>VKORC1</i>, <i>CYP4F2</i>, and <i>GGCX</i> polymorphisms, as well as other clinical and demographic factors, for 5-year mortality in patients with acute ischemic stroke (AIS). <i>Materials and Methods</i>: The study enrolled 252 patients who were consecutively hospitalized for AIS. Demographic data, comorbidities, and laboratory tests were collected. Genotyping of the <i>VKORC1</i> rs9923231 (-1639G > A; VKORC1*2), <i>CYP4F2</i> rs2108622 (1347C > T), and <i>GGCX</i> rs11676382 (12970C > G) polymorphisms was performed. Mortality was noted if it occurred within five years following the 30 days after discharge, using the National Health Insurance House registry. <i>Results</i>: Death was recorded in 71 (28.1%) patients. In multivariate analysis the following variables were independent variables associated with 5-year mortality: age > 72 years (OR 2.83 (95%CI 1.32; 6.08), <i>p</i> = 0.007), a lesion volume > 12.6 mL (OR 4.05 (95%CI 2.05; 7.99), <i>p</i> < 0.001), and an NIHSS score > 7 (OR-2.64 (95%CI 1.31; 5.31), <i>p</i> = 0.006). <i>VKORC1</i> (-1639G > A) SNP m/m variant was only marginally associated with mortality. <i>Conclusions</i>: In this study which included AIS patients, <i>VKORC1</i>, <i>CYP4F2</i>, and <i>GGCX</i> polymorphisms did not independently predict mortality. The <i>VKORC1</i> variant was only marginally associated with mortality, but this was attenuated after correction for multiple testing. Advanced age, NIHSS score, and the lesion volume were independent predictors of long-term mortality in AIS patients.