The causal relationship between platelet indices and liver cancer: a bidirectional two-sample Mendelian randomization study
The bidirectional causal relationship between platelet indices and liver cancer may be mediated by confounding factors such as liver cirrhosis. Further validation through mediation MR analyses or larger-scale replication studies is required to elucidate these causal pathways.
Authors
- Shengni Hua (ORCID: https://orcid.org/0000-0002-6014-1476)
- Xiaohui Zhao (ORCID: https://orcid.org/0000-0001-6852-0975)
- Yusheng Shi (ORCID: https://orcid.org/0000-0003-1124-6383)
- Yuzhe Zhang (ORCID: https://orcid.org/0009-0009-0753-1318)
- Zhengsheng Yi
- Xin He
Institutions
- Zhuhai People's Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1007/s12672-025-03536-6
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China