DNMT3A-R882 mutation promotes acute myeloid leukemia progression by recruiting E2H2 to inhibit circKCNQ5 methylation
DR882MUT promotes AML progression by inhibiting circKCNQ5 methylation to upregulate circKCNQ5 expression. DR882WT enhanced circKCNQ5 methylation, which requires EZH2 participation.
Authors
- Rong Xu (ORCID: https://orcid.org/0000-0002-7744-6321)
- Liuyan Xin
- Yijian Chen (ORCID: https://orcid.org/0000-0002-5757-684X)
- Pengxiang Xu
- Lin Li (ORCID: https://orcid.org/0000-0002-6798-023X)
- Liqun Zhang (ORCID: https://orcid.org/0000-0001-6570-2749)
- Xiaodan Zhu
- Chuanming Lin
Institutions
- First Affiliated Hospital of Gannan Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1007/s12672-025-03347-9
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China