Structural Elucidation and Antiviral Activity Evaluation of Novelly Synthesized Guaiazulene Derivatives
A series of guaiazulene derivatives were efficiently synthesized by one-step reaction using guaiazulene as the substrate. Their structures were fully characterized by comprehensive spectroscopic methods, and their antiviral activities against influenza A (H1N1) virus were evaluated. Compounds <b>2b</b>, <b>2d</b>, <b>2e</b>, <b>2f</b>, <b>3a</b>, and <b>3b</b> exhibited significant anti-influenza activity, with IC<sub>50</sub> values of 89.03 µM, 98.48 µM, 78.38 µM, 108.20 µM, 50.96 µM, and 56.09 µM, respectively. Ribavirin was used as a positive control (IC<sub>50</sub> = 130.22 µM).
Authors
- Lei Hou (ORCID: https://orcid.org/0000-0002-8022-0729)
- Guoqiang Li (ORCID: https://orcid.org/0000-0003-3223-4007)
- Canling Cheng
- Xuli Tang (ORCID: https://orcid.org/0000-0002-4498-9485)
Institutions
- Zaozhuang University (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Marine Drugs
- Published
- 2025-09-28
- DOI
- https://doi.org/10.3390/md23100387
- Primary Topic
- Photochromic and Fluorescence Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ocean University of China
- Zaozhuang University
- National Key Research and Development Program of China