Qushi huayu decoction dose-dependent inhibition of caspase-2/SREBP-1 in MASLD mice
QHD exhibits dose-dependent, complementary effects in MASLD, with low doses improving lipid metabolism and insulin sensitivity, and high doses more effectively suppressing Caspase-2/SREBP-1 and inflammatory signaling. This dual action underscores its broad regulation of ER stress and supports stage-specific, hierarchical dosing strategies aligned with traditional Chinese medicine principles.
Authors
- Shuang Li (ORCID: https://orcid.org/0009-0003-4563-8112)
- Zuxi Gu (ORCID: https://orcid.org/0009-0004-4421-2483)
- Xiaoping Shen
- Xin Xin (ORCID: https://orcid.org/0000-0003-4899-9127)
- Qian Liu (ORCID: https://orcid.org/0000-0001-8224-0427)
- Xiaojun Gou
- Lingling Hou
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- Baoshan University (CN)
- Shuguang Hospital (CN)
Publication Details
- Journal
- Hereditas
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s41065-025-00561-x
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Natural Science Foundation of China
- Shanghai University of Traditional Chinese Medicine