A GelMA/polydopamine hydrogel with PTH and osteogenically stimulated alveolar mucosa-derived stem cells promotes bone regeneration in MRONJ-affected wounds
GelMA/PD loaded with PTH and microRNA-218-transfected AMCs could facilitate mucosal healing, recover the osteoblast-osteoclast coupling, and repair MRONJ-affected wounds, and might be a feasible strategy for managing MRONJ.
Authors
- Ming‐Hsu Chen (ORCID: https://orcid.org/0000-0002-0348-3939)
- Wei‐Chiu Tai
- Yu-Ting Lin (ORCID: https://orcid.org/0000-0003-4394-811X)
- Jiashing Yu (ORCID: https://orcid.org/0000-0002-0782-2328)
- Po‐Chun Chang (ORCID: https://orcid.org/0000-0002-4493-6922)
- Kuang Lin (ORCID: https://orcid.org/0000-0003-3017-6026)
- Guan‐Yu Lan
- Che‐Chang Tu
Institutions
- Kaohsiung Medical University (TW)
- National Taiwan University (TW)
- Cathay General Hospital (TW)
- National Taiwan University Hospital (TW)
- National Taipei University of Business (TW)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s13287-025-04655-1
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cathay General Hospital
- National Taiwan University Hospital
- National Taiwan University
- National Science and Technology Council