The PCNA inhibitor AOH1996 suppresses cancer stemness and enhances anti-PD1 immunotherapy in squamous cell carcinoma
Taken together, our results demonstrated that AOH1996 suppressed tumor growth, eliminated cancer stem cells (CSCs), and synergistically enhanced the efficacy of anti-PD1 immunotherapy in HNSCC.
Authors
- Lingfei Jia (ORCID: https://orcid.org/0000-0002-1227-1233)
- Zhen Qin (ORCID: https://orcid.org/0000-0003-0421-3938)
- Baoxin Gu (ORCID: https://orcid.org/0000-0002-0141-3056)
- Yiwen Chen (ORCID: https://orcid.org/0000-0002-1594-8908)
- Yujia Wang (ORCID: https://orcid.org/0009-0009-1725-5839)
Institutions
- Peking University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s13287-025-04607-9
- Citations
- 1
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80