Elevation of tTG-IgA Antibodies in a Prospective Cohort of Children at Risk of Celiac Disease: Insights From the CDGEMM Cohort
Celiac disease (CeD) is a common immune-mediated condition that occurs in genetically predisposed individuals. In this study, we examined the trajectory of tissue transglutaminase IgA (tTG-IgA) antibodies in a prospective longitudinal cohort of over 500 children at risk of developing CeD due to having a first-degree relative with CeD. We identified 34 subjects from our cohort and examined tTG-IgA titers at seroconversion and 6 months before tTG-IgA seroconversion. We found that all subjects had normal tTG-IgA 6 months before seroconversion. Thus, we conclude that tTG-IgA elevation in subjects with CeD is a sudden event and its trajectory cannot be used as a marker to predict seroconversion in this population.
Authors
- Federica Malerba (ORCID: https://orcid.org/0000-0002-9105-0630)
- Naire Sansotta (ORCID: https://orcid.org/0000-0002-8799-7266)
- K. Cortessis Victoria
- Michela Perrone (ORCID: https://orcid.org/0000-0002-1318-7922)
- Luca Elli (ORCID: https://orcid.org/0000-0002-0873-0759)
- Francesco Valitutti (ORCID: https://orcid.org/0000-0002-1473-2240)
- Annalisa Morelli (ORCID: https://orcid.org/0000-0002-9052-0266)
- Trovato Chiara Maria
- Cristofori Fernanda
- Paolo Pasqua
- Alessio Fasano (ORCID: https://orcid.org/0000-0002-2134-0261)
- Maureen M. Leonard (ORCID: https://orcid.org/0000-0002-5955-5102)
- Lorenzo Norsa (ORCID: https://orcid.org/0000-0003-3322-2921)
- Marco Crocco (ORCID: https://orcid.org/0000-0001-7277-4767)
- Ruggiero Francavilla (ORCID: https://orcid.org/0000-0002-4603-974X)
- Monica Montuori (ORCID: https://orcid.org/0000-0003-2383-5177)
- Giovanni Di Nardo (ORCID: https://orcid.org/0000-0002-9026-7758)
- Maria Elisabetta Baldassarre (ORCID: https://orcid.org/0000-0003-0590-6664)
- P. Cremona Tiziana
- P. Valentina
Institutions
- University of Salerno (IT)
- University of Milan (IT)
- University of Perugia (IT)
- Istituto Giannina Gaslini (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Ospedale Maggiore (IT)
- Ospedale Papa Giovanni XXIII (IT)
- MaineGeneral Medical Center (US)
- European Biomedical Research Institute of Salerno (IT)
- Bambino Gesù Children's Hospital (IT)
- Ospedale dei Bambini Vittore Buzzi (IT)
- Ospedale Pediatrico Giovanni XXIII (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Bari Aldo Moro (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- The American Journal of Gastroenterology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.14309/ajg.0000000000003772
- Citations
- 1
- Primary Topic
- Celiac Disease Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.81