An integrative bioinformatic and Mendelian randomization study exploring the role of polyunsaturated fatty acid metabolism in laryngeal cancer
Our findings suggest a potential mechanistic link between PUFA metabolism and LC susceptibility, generating hypotheses that PUFA-associated pathways may modulate immune microenvironment characteristics. This computational study provides preliminary insights into potential immunometabolic therapeutic strategies in laryngeal cancer that warrant experimental validation.
Authors
- Lina Qin (ORCID: https://orcid.org/0000-0002-6625-0198)
- Xueyan Ren (ORCID: https://orcid.org/0000-0003-3824-0088)
- Lina Peng (ORCID: https://orcid.org/0000-0001-6331-4822)
- Jing Hu (ORCID: https://orcid.org/0000-0001-7604-6732)
- Qian Zhao (ORCID: https://orcid.org/0000-0003-1795-9560)
- Haibin Ma
- H.-J. Han
- Zi-Hao Wang (ORCID: https://orcid.org/0000-0001-6368-2158)
Institutions
- Handan College (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1007/s12672-025-03578-w
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00