MSCs-derived HGF alleviates senescence after AKI by modulating mitoSTAT3-controlled copper flux and respiration
HUC-MSCs-derived HGF promotes STAT3 mitochondrial translocation via cMet, enhancing mitochondrial respiration and copper excretion through COX17, thereby reducing renal senescence after AKI.
Authors
- Xumin Zheng
- Yuhao Chen (ORCID: https://orcid.org/0009-0006-3669-101X)
- Yue Liang (ORCID: https://orcid.org/0000-0002-5925-6743)
- Guangyan Cai (ORCID: https://orcid.org/0000-0001-8586-6353)
- Xu Cheng (ORCID: https://orcid.org/0000-0002-1577-7627)
- Zhe Feng (ORCID: https://orcid.org/0000-0002-7851-8999)
- Y Zhang (ORCID: https://orcid.org/0000-0002-1222-3872)
- Kaiting Zhuang (ORCID: https://orcid.org/0000-0002-1184-3279)
- Wenjuan Wang (ORCID: https://orcid.org/0000-0003-3863-9937)
- Siyang Wang (ORCID: https://orcid.org/0000-0002-4009-0800)
- Xiangmei Chen (ORCID: https://orcid.org/0000-0001-5790-4789)
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s13287-025-04653-3
- Citations
- 1
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 1.12
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation