Identification and validation of centrosome-related features predicting prognosis in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is commonly linked with centrosome abnormalities that contribute to chromosomal instability and tumor progression. Four prognostic centrosome-related genes (CRGs): DYNLL1, CEP85, C10orf90, and CETN1 were utilized to develop a risk model for HCC. The model demonstrated strong prognostic reliability. Both risk score and risk group served as independent prognostic predictors for HCC. Further analyses revealed that the low-risk group was associated with metabolism and detoxification pathways and exhibited a lower abundance of M2 macrophages. Additionally, high expression levels of DYNLL1 and CETN1 were significantly correlated with poorer prognosis, with upregulation of DYNLL1 confirmed in HCC patients.