Photoperiodic responsiveness in the DNA methylation and gene expression in the hypothalamus of ovariectomized and estradiol-treated ewes
This study generated the whole-genome single-base resolution DNA methylome maps of sheep hypothalamus under different photoperiods, and elucidated the regulatory relationship between DNA methylation and photoperiod-dependent seasonal reproduction in sheep hypothalamus tissues. Our findings provided a valuable resource for further research on the underlying mechanisms of the hypothalamic-regulated reproductive seasonality in sheep.
Authors
- Xiaosheng Zhang (ORCID: https://orcid.org/0000-0001-9719-0573)
- Ran Di (ORCID: https://orcid.org/0000-0003-3450-738X)
- Mingxing Chu (ORCID: https://orcid.org/0000-0002-5164-0310)
- Xiaofei Guo (ORCID: https://orcid.org/0000-0002-9516-4782)
- Qiuyue Liu (ORCID: https://orcid.org/0000-0002-6643-1730)
- Xiaoyun He (ORCID: https://orcid.org/0000-0002-2159-5635)
- Xiangyu Wang (ORCID: https://orcid.org/0000-0001-7375-8937)
- Jinlong Zhang (ORCID: https://orcid.org/0000-0003-3158-2130)
Institutions
- Institute of Genetics and Developmental Biology (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Institute of Animal Sciences (CN)
- Tianjin Academy of Agricultural Sciences (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s12864-025-12066-y
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Earmarked Fund for China Agriculture Research System
- Agricultural Science and Technology Innovation Program