Multi-omics protein signaling networks identify sex-specific therapeutic candidates in lung adenocarcinoma
Our findings underscore the importance of considering sex differences in lung adenocarcinoma molecular profiles. The integration of transcriptomic and proteomic data reveals sex-specific pathways and potential therapies, paving the way for personalized treatment approaches tailored to male and female patients.
Authors
- Enakshi Saha (ORCID: https://orcid.org/0000-0003-2938-539X)
- Camila M. Lopes‐Ramos (ORCID: https://orcid.org/0000-0003-0284-7371)
- Viola Fanfani (ORCID: https://orcid.org/0000-0003-3852-6908)
- Dawn L. DeMeo (ORCID: https://orcid.org/0000-0001-9653-0636)
- Katherine H. Shutta (ORCID: https://orcid.org/0000-0003-0402-3771)
- Megha Padi (ORCID: https://orcid.org/0000-0002-3446-4562)
- Kimberly Glass (ORCID: https://orcid.org/0000-0003-4394-5779)
- John Quackenbush (ORCID: https://orcid.org/0000-0002-2702-5879)
- Marouen Ben Guebila (ORCID: https://orcid.org/0000-0001-5934-966X)
- Jonas Fischer (ORCID: https://orcid.org/0000-0003-4225-9734)
- Chen Chen (ORCID: https://orcid.org/0000-0002-8042-7201)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of Arizona (US)
- Max Planck Institute for Informatics (DE)
- Dana-Farber Cancer Institute (US)
- Dana-Farber/Harvard Cancer Center (US)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s13293-025-00752-1
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Institutes of Health