The systemic effect of prolonged use of sodium alendronate on the peri-implant bone repair process
the alendronate treatment stabilized the bone-implant interface over time, suggesting a protective effect against osteoporotic bone loss despite a delayed initial response. In the long term, the group systemically treated with alendronate showed improved bone formation around the implants, outperforming the control group. However, future research is essential to prevent possible negative impacts on osseointegration in patients taking this medication.
Authors
- Pedro Henrique Silva Gomes-Ferreira (ORCID: https://orcid.org/0000-0002-8936-3662)
- Daniele Botticelli (ORCID: https://orcid.org/0000-0003-2804-1632)
- Paula Buzo Frigério (ORCID: https://orcid.org/0000-0002-5012-5093)
- Naara Gabriela Monteiro (ORCID: https://orcid.org/0000-0002-2857-9195)
- Roberta Okamoto (ORCID: https://orcid.org/0000-0002-6773-6966)
- Daniel Silva LEÃO (ORCID: https://orcid.org/0000-0002-2321-0882)
Institutions
- Linde (Italy) (IT)
- Centro Universitário Euroamericano (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Journal of Applied Oral Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1590/1678-7757-2025-0085
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00