Metagenomic next-generation sequencing for pathogen detection of pulmonary infections in persons living with HIV
mNGS comprehensively characterizes the complex pathogen spectrum in PLWH-associated pulmonary infections, significantly enhancing detection sensitivity for mixed and fastidious infections, thereby guiding targeted anti-infective therapy. Immunosuppression severity strongly correlates with opportunistic pathogen profiles and the risk of specific pathogen detection, highlighting the importance of immune status-guided clinical strategies. mNGS serves as a valuable adjunct to conventional diagnostic methods, enhancing the detection and prognostic assessment of infectious complications in PLWH.
Authors
- Yong Wu (ORCID: https://orcid.org/0000-0002-3667-8716)
- Shaowei Guo (ORCID: https://orcid.org/0000-0002-7930-1388)
- Yapeng Zhang (ORCID: https://orcid.org/0000-0003-0266-0443)
- Li-hua Lu
- Yimin Li
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
- University of South China (CN)
Publication Details
- Journal
- AIDS Research and Therapy
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s12981-025-00801-0
- Citations
- 1
- Primary Topic
- Pneumocystis jirovecii pneumonia detection and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35