The Founders’ 400 and Chicago Perinatal Origins of Disease study protocol: Following a prospective, longitudinal cohort from early pregnancy through two years of postnatal life

CPOD is a unique, prospective, observational study that includes a large, ethnically diverse cohort; rich, multifactorial phenotypic characterization of maternal health and pregnancy outcomes, neonatal health, and early childhood neurobehavior; and development of a biorepository of social, environmental, and clinical data and biospecimens from early pregnancy to two years of postnatal life. Using translational science approaches, data from this cohort will provide clinical and mechanistic insights into how environmental and psychosocial exposures, both during pregnancy and transgenerationally, influence changes in the underlying biology of maternal-child dyads, and how these changes are associated with the risk of adverse health outcomes that contribute to future disease.