Physical activity is associated with exercise capacity among patients undergoing chemotherapy: A pilot randomized controlled trial
Baseline data indicate that, on average, our study sample was close to meeting the PA guidelines. Unexpectedly, both groups maintained their activity levels up to 3- and 6-months. Submaximal exercise capacity (6MWD) was also maintained (with a clinically meaningful but not statistically significant relative benefit in the PAI) suggesting higher PA levels may associate with reduced exercise intolerance after anthracycline therapy.
Authors
- Jeremy Via (ORCID: https://orcid.org/0000-0002-5363-6155)
- Alexander R. Lucas (ORCID: https://orcid.org/0000-0001-7318-3387)
- Amy C. Ladd
- Shannon L. Mihalko (ORCID: https://orcid.org/0000-0003-1270-2520)
- Juliana Costa (ORCID: https://orcid.org/0000-0002-2375-3430)
- Alexandra Marshall
- Peter H. Brubaker (ORCID: https://orcid.org/0000-0003-0918-4056)
- Sam Norton (ORCID: https://orcid.org/0000-0003-1714-9963)
- W. Gregory Hundley (ORCID: https://orcid.org/0000-0002-2433-8853)
- R. Lee Franco
- Victor Yazbeck (ORCID: https://orcid.org/0000-0001-5113-8681)
- Lynne I. Wagner (ORCID: https://orcid.org/0000-0001-9685-4796)
- A Antonucci (ORCID: https://orcid.org/0009-0004-1182-9807)
- Rakhee Vaidya
Institutions
- University of North Carolina at Chapel Hill (US)
- Virginia Commonwealth University (US)
- Wake Forest University (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1371/journal.pone.0329774
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00