Exploring local adjuvant antibiotics as viable alternative to systemic antibiotics in non-surgical periodontal therapy: Clinical, immunological and microbiological insights

The adjuvant use of piperacillin + tazobactam led to the comparable improvement of clinical, microbiological and immunological parameters to the conventional use of amoxicillin and metronidazol combination six months following the initial therapy of periodontitis. Therefore, these locally delivered antibiotics might be a promising alternative to the standard use of systemic amoxicillin and metronidazol combination during initial therapy of stage III periodontitis.