Machine learning-based transcriptomic analysis identifies NAMPT and SAT1 as potential biomarkers and therapeutic targets in ferroptosis-associated rheumatoid arthritis
NAMPT, CISD2, LACTB, PRNP, SAT1, SOD2, MITD1, and FASN may modulate ferroptosis and RA by influencing immunity, and NAMPT and SAT1 contribute significantly to the diagnosis and treatment of the disease. Future studies focusing on validating these genes in larger cohorts and exploring their therapeutic potential will provide deeper insights.
Authors
- Vino Sundararajan (ORCID: https://orcid.org/0000-0002-0015-8460)
- Devi Soorya Narayana Sasikumar
Institutions
- Vellore Institute of Technology University (IN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1371/journal.pone.0333556
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52