Latin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol
Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.
Authors
- Mauricio A. Yanez
- David Andina Martínez (ORCID: https://orcid.org/0000-0002-3082-8832)
- Tania Pérez Duarte
- Joali Alexandra Juárez Lujambio
- Dayan Berrones
- Tim B. Bigdeli (ORCID: https://orcid.org/0000-0003-2215-5946)
- Luisa F. Daza
- Ethan J. Schweissing (ORCID: https://orcid.org/0000-0001-5795-804X)
- Tomas Fazio
- Jessica M. Chire
- Joseph D. Hovey (ORCID: https://orcid.org/0000-0002-3968-0942)
- Alonso Morales‐Rivero (ORCID: https://orcid.org/0000-0002-9015-4390)
- Paul Daniel Arnold (ORCID: https://orcid.org/0000-0003-2496-4624)
- Reinhard Janssen‐Aguilar (ORCID: https://orcid.org/0000-0001-5340-9078)
- Lucas C. Quarantini (ORCID: https://orcid.org/0000-0002-8807-8464)
- Diana Rancourt (ORCID: https://orcid.org/0000-0002-0241-1327)
- Andres González (ORCID: https://orcid.org/0000-0001-9660-7090)
- Tomás Miño
- Alejandra Ruiz‐Velasco
- Zainab Naqqash
- Caleb W. Lack (ORCID: https://orcid.org/0000-0002-1103-2759)
- Monicke O. Lima (ORCID: https://orcid.org/0000-0003-0747-2345)
- Jennifer Crosbie (ORCID: https://orcid.org/0000-0002-8710-3322)
- Jerry Guintivano (ORCID: https://orcid.org/0000-0003-3541-1101)
- Jonathan S. Abramowitz (ORCID: https://orcid.org/0000-0002-1721-8060)
- Nuria Lanzagorta (ORCID: https://orcid.org/0000-0001-6769-6813)
- Pablo R. Moya (ORCID: https://orcid.org/0000-0001-6409-1544)
- Jennifer L. Callahan (ORCID: https://orcid.org/0000-0001-9190-3886)
- Belinda E. Núñez Bracho
- Alexie Vallejo‐Silva
- Wayne K. Goodman (ORCID: https://orcid.org/0000-0001-6717-082X)
- Raquel Marina Zepeda-Burgos
- Iliana Ortega
- S. Evelyn Stewart (ORCID: https://orcid.org/0000-0002-0994-6383)
- Renato T. Ramos (ORCID: https://orcid.org/0000-0001-6798-5228)
- NaEshia Ancalade (ORCID: https://orcid.org/0000-0002-4844-129X)
- Carolina Cappi (ORCID: https://orcid.org/0000-0001-6661-3756)
- Ambar A. Núñez Bracho
- Caitlyn E. Maye (ORCID: https://orcid.org/0000-0002-7901-9489)
- Luz M. Zappa
- Maria de Los Angeles Matos
- Sophie C. Schneider (ORCID: https://orcid.org/0000-0002-1469-7764)
- Aline S. Sampaio (ORCID: https://orcid.org/0000-0001-5568-6167)
- Cynthia N. Barrera
- Joseph F. Mcguire (ORCID: https://orcid.org/0000-0002-6128-8138)
- Laura Marcela Barón Castaño (ORCID: https://orcid.org/0000-0003-2789-3390)
- Gabriel Lázaro‐Muñoz (ORCID: https://orcid.org/0000-0003-1933-9453)
- Saira A. Weinzimmer (ORCID: https://orcid.org/0000-0003-0725-839X)
- Javier Vargas‐Medrano (ORCID: https://orcid.org/0000-0002-5424-4225)
- Laura D. Gonzalez (ORCID: https://orcid.org/0000-0001-8395-1925)
- Diego A. Forero (ORCID: https://orcid.org/0000-0001-9175-3363)
- Hailiang Huang (ORCID: https://orcid.org/0000-0003-1461-5762)
- Keaton J. Soileau (ORCID: https://orcid.org/0000-0002-5564-3738)
- Humberto Nicolini (ORCID: https://orcid.org/0000-0003-2494-0067)
- Victor R. Adorno
- Gabriela M. Ferreira (ORCID: https://orcid.org/0000-0002-0094-4154)
- Melanie O. Longhurst
- Yana Quarantini‐Alvim
- Daniel L. Costa (ORCID: https://orcid.org/0000-0001-7916-8567)
- Karen G. Martinez‐Gonzalez
- Carolyn I. Rodríguez (ORCID: https://orcid.org/0000-0001-6697-1692)
- Andrew G. Guzick
- Vanessa R. Ramos (ORCID: https://orcid.org/0000-0001-5735-7690)
- Maria E. Moreira‐de‐Oliveira (ORCID: https://orcid.org/0000-0001-5005-7994)
- Nasim Khalfe (ORCID: https://orcid.org/0000-0002-1719-1996)
- Elise V. Ray
- Guillermo Dager
- John R. Best (ORCID: https://orcid.org/0000-0001-5775-7053)
- Izabela Guimarães Barbosa (ORCID: https://orcid.org/0000-0002-4480-0195)
- Eurı́pedes Constantino Miguel (ORCID: https://orcid.org/0000-0002-9393-3103)
- Margaret A. Richter (ORCID: https://orcid.org/0000-0001-5450-2936)
- Lucila Fay
- Kesley A. Ramsey (ORCID: https://orcid.org/0000-0002-3512-0913)
- Joseph D. Buxbaum (ORCID: https://orcid.org/0000-0001-8898-8313)
- Jose L. Perales Orellana
- Bradley C. Riemann (ORCID: https://orcid.org/0000-0002-7339-3525)
- Polaris Gonzalez‐Barrios
- Maritza Dorila Placencia Medina (ORCID: https://orcid.org/0000-0003-3624-3461)
- Vissente Tapia‐Cuevas (ORCID: https://orcid.org/0009-0004-3884-2972)
- Gilberto Sousa Alves (ORCID: https://orcid.org/0000-0002-0463-6183)
- Paola Giusti‐Rodríguez (ORCID: https://orcid.org/0000-0002-1921-1305)
- Elizabeth G. Atkinson (ORCID: https://orcid.org/0000-0002-6308-776X)
- Stacey Pereira (ORCID: https://orcid.org/0000-0001-6541-3904)
- Alexandra Z. Jimenez Reynolds
- Journa Cobite
- Carolina Blaya Dreher (ORCID: https://orcid.org/0000-0001-9157-7785)
- María Belén Prieto
- James J. Crowley (ORCID: https://orcid.org/0000-0001-9051-1557)
- Leonardo Cardoso Saraiva (ORCID: https://orcid.org/0000-0001-8362-2566)
- María Beatriz Moyano
- Maria Cecília B. Carneiro
- Mariel Paz y Miño (ORCID: https://orcid.org/0000-0003-2285-7032)
- Camilo J. Ruggero (ORCID: https://orcid.org/0000-0002-8482-6269)
- Kelly L. Piacsek
- Roseli Gedanke Shavitt (ORCID: https://orcid.org/0000-0001-5959-5748)
- Circe Montes de
- Elba S. Luna
- Jacey L Anderberg (ORCID: https://orcid.org/0000-0002-5434-5800)
- Guadalupe Vidal Martínez
- Anthony W. Zoghbi
- Kiara R. Timpano (ORCID: https://orcid.org/0000-0002-0665-8722)
- Victor O. Cruz (ORCID: https://orcid.org/0000-0003-2676-1601)
- Matthew Halvorsen (ORCID: https://orcid.org/0000-0002-6707-2418)
- Madison A. Knutsen
- Jonathan S. Comer (ORCID: https://orcid.org/0000-0001-6872-4476)
- Bharathi S. Gadad
- Ainsley K. Patrick (ORCID: https://orcid.org/0000-0001-7975-1306)
- Olivia J. Morris (ORCID: https://orcid.org/0000-0003-2721-989X)
- Andrew D. Wiese (ORCID: https://orcid.org/0000-0002-5181-0674)
- Sandra Ivonne Muñoz Maldonado (ORCID: https://orcid.org/0000-0002-9392-5023)
- Michele T. Pato (ORCID: https://orcid.org/0000-0002-4589-7398)
- Macarena Churruca Muñoz
- Daphne M. Ayton (ORCID: https://orcid.org/0000-0002-3822-7310)
- Edith G. Figueroa
- Alejandro A. Arellano Espinosa
- Sara Mithani
- Charlene Minaya (ORCID: https://orcid.org/0000-0002-8802-8942)
- Fernanda Zetola Delage
- María I. Vásquez
- Beatriz Treviño‐de la Garza
- Pamela Claisse Quiroz
- María Celeste Berardo
- Daniele T. H. Fragoso
- Ygor Arzeno Ferrão (ORCID: https://orcid.org/0000-0003-3770-5912)
- Juan Carlos Rivas (ORCID: https://orcid.org/0000-0002-3497-4036)
- Leonardo F. Fontenelle (ORCID: https://orcid.org/0000-0001-9075-8226)
- Gustavo S. Alves (ORCID: https://orcid.org/0000-0002-8335-4925)
- Luis A. Olavarria Castaman
- Matias Jensen (ORCID: https://orcid.org/0000-0003-1327-031X)
- Tamara Peregrina
- Mayra C Martinez Mallen
- Marcos E Ochoa-Panaifo
- Tania Borda
- Gwyneth Zai (ORCID: https://orcid.org/0000-0002-0894-6867)
- Ángel Alberto Ruíz-Chow (ORCID: https://orcid.org/0000-0002-6562-0935)
- Russell Schachar (ORCID: https://orcid.org/0000-0002-2015-4395)
- Evelyn Chazelle
- Iaroslava C. Ramos
- Emily Strouphauer (ORCID: https://orcid.org/0000-0002-3967-8500)
- Renee M Frederick
- Laura D. Seligman (ORCID: https://orcid.org/0000-0002-6025-5975)
- Maria Corina Ochoa Rojas
- Darpan I. Patel (ORCID: https://orcid.org/0000-0001-8124-8072)
- Daniela del Río
- Bárbara Perdigão Stumpf (ORCID: https://orcid.org/0000-0003-2987-5153)
- Anabel De la Rosa-Gómez (ORCID: https://orcid.org/0000-0002-3527-1500)
- Molly S. Martinez
- Cinthia Aguirre
- Daniel Guttfreund
- Dorothy E. Grice (ORCID: https://orcid.org/0000-0002-8833-2549)
- Maria Conceição do Rosário (ORCID: https://orcid.org/0000-0002-9687-0072)
- Shaina B. Storch
- Eric A. Storch (ORCID: https://orcid.org/0000-0002-7631-3703)
- Christie L. Burton (ORCID: https://orcid.org/0000-0002-8955-6528)
- Manuel Mattheisen (ORCID: https://orcid.org/0000-0002-8442-493X)
- Trinidad Olivos Balmaceda
- Melisa N. Sagarnaga
- Jonathan Irreño‐Sotomonte
- Andrea Horvath Marques
- Sheldon R. Garrison (ORCID: https://orcid.org/0000-0003-0745-629X)
- Lina Maria Zapata‐Restrepo (ORCID: https://orcid.org/0000-0002-9615-4981)
- Sandra L. Cepeda (ORCID: https://orcid.org/0000-0002-6787-6555)
- Minjee Kook
- Marco A. González
- Gabriela B. de Menezes (ORCID: https://orcid.org/0000-0003-4117-9767)
- Latin American Trans‐ancestry INitiative for OCD genomics
- Brazilian Obsessive‐Compulsive Spectrum Disorder Working Group
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- UNC Libraries
- Published
- 2025-03-19
- DOI
- https://doi.org/10.17615/m9dh-8h95
- Primary Topic
- Copyright and Intellectual Property
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Beatrice and Samuel A. Seaver Foundation
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- National Institute of Mental Health