Passive surveillance of human African trypanosomiasis in the Democratic Republic of the Congo: clinical presentation and prospective evaluation of rapid diagnostic and reference laboratory test accuracy
Compared to the WHO's target product profiles for gambiense HAT RDTs, the HAT Sero K-SeT RDT had ideal sensitivity but its specificity was on the borderline of minimally acceptable. Sub-optimal sensitivities of trypanolysis and to a lesser extent, indirect ELISA/T.b. gambiense when applied on DBS, were confirmed. Molecular tests for remote testing need to be improved and evaluated further.
Authors
- Jacquies Makabuza
- Pathou Nganzobo
- Crispin Lumbala (ORCID: https://orcid.org/0000-0001-8892-1610)
- Jean Kwete
- Nicolas Bebronne (ORCID: https://orcid.org/0000-0003-3542-309X)
- Ipos Ngay Lukusa
- Veerle Lejon (ORCID: https://orcid.org/0000-0002-6795-0962)
- Erick Mwamba Miaka (ORCID: https://orcid.org/0000-0001-7624-7905)
- Philippe Büscher (ORCID: https://orcid.org/0000-0002-1926-7472)
- Alain Fukinsia
- Dieudonné Mumba Ngoyi (ORCID: https://orcid.org/0000-0002-5886-2004)
Institutions
- Centre de Coopération Internationale en Recherche Agronomique pour le Développement (FR)
- Université de Montpellier (FR)
- University of Mbuji Mayi (CD)
- National Institute of Biomedical Research (CD)
- Programme National Multisectoriel de Lutte contre le sida (CD)
- Institut de Recherche pour le Développement (FR)
- Instituut voor Tropische Geneeskunde (BE)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1371/journal.pntd.0013045
- Citations
- 1
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 1.35