BRD-K20733377 inhibits ferroptosis and alleviates intervertebral disc degeneration via the STAT3/NFKB1 axis: a multiapproach study
BRD-K20733377 inhibits ferroptosis through the STAT3/NFKB1 axis, thereby alleviating IVDD. This provides a new perspective for the study of IVDD and could serve as a potential therapeutictarget for IVDD.
Authors
- Hao Wu (ORCID: https://orcid.org/0000-0002-7356-5841)
- Chen Liu (ORCID: https://orcid.org/0000-0002-8924-0582)
- Bingxuan Hua
- You Xuan
- Yongbo Zhang (ORCID: https://orcid.org/0009-0008-3239-8013)
- Zhaoyu Li (ORCID: https://orcid.org/0000-0002-6275-7469)
- Zhengguang Li
- Liang Zhang
- Hua Sun
- Shuangjia Zai
Institutions
- Xuzhou Medical College (CN)
- Northern Jiangsu People's Hospital (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s13287-025-04662-2
- Citations
- 2
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.94