Visible‐Light Driven Radical Cyclization Strategy for C(sp ³ )─CH ₂ CF ₃ ─Functional Tetrahydroquinoline Derivatives

Abstract We have successfully developed a photocatalytic radical cascade cyclization reaction for the efficient synthesis of tetrahydroquinoline derivatives with diverse structural variations. This method enables the one‐pot synthesis of tetrahydroquinolines with high yields, offering a valuable strategy for construction of C(sp 3 )─CH 2 CF 3 containing molecules. The approach features low catalyst load, excellent regioselectivity, and a broad substrate scope, all under mild reaction conditions. Furthermore, the selectivity for mono‐ and di‐trifluoromethylated products can be fine‐tuned by adjusting the amount of Togni's reagent II and the choice of solvent.