Human umbilical cord mesenchymal stem cell-derived exosomes prevent and alleviate experimental pulmonary fibrosis by modulating the cytoskeleton of macrophages
Our findings demonstrate that hucMSC-Exos alleviate pulmonary inflammation, slow lung fibrosis, inhibit macrophage pyroptosis, activate the actin cytoskeleton signaling pathway, and maintain plasma membrane integrity in silicotic mice. This study provides possible therapeutic targets and molecular mechanisms for silicosis, establishing a link among silicosis, cytoskeleton, and pyroptosis, while validating the protective effect of hucMSC-Exos on the lungs of silicotic mice.
Authors
- Bingbing Wu (ORCID: https://orcid.org/0000-0001-9269-4414)
- Xi Shen (ORCID: https://orcid.org/0000-0001-9669-6521)
- Hao Yan (ORCID: https://orcid.org/0000-0002-5418-0516)
- Zhenghao Liu (ORCID: https://orcid.org/0000-0003-3791-0780)
- Sanqiao Yao (ORCID: https://orcid.org/0000-0002-8172-9770)
- Jinlong Li (ORCID: https://orcid.org/0000-0002-0915-4095)
- Liyuan Zhao (ORCID: https://orcid.org/0009-0004-4428-7805)
- Fuhai Shen (ORCID: https://orcid.org/0000-0003-3534-8958)
- Shuyu Xiao
- Yiwen Tang (ORCID: https://orcid.org/0009-0005-8579-451X)
Institutions
- North China University of Science and Technology (CN)
- Tangshan College (CN)
- Tangshan People's Hospital (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1186/s13287-025-04646-2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hebei Province