Observational studies of early versus late salvage therapies in critical care exhibit intrinsic selection bias: two meta-analyses

There were significant differences in the results of observational and experimental studies looking at timing of salvage therapies, partly due to selection bias in observational studies. This issue was worsened by only including subjects who receive the therapy. Randomized trials using objective eligibility criteria remain the best method to determine optimal timing of salvage therapies.

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Publication Details

Journal
Critical Care
Published
2025-09-29
DOI
https://doi.org/10.1186/s13054-025-05663-6
Citations
1
Primary Topic
Sepsis Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
1.35
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article

Observational studies of early versus late salvage therapies in critical care exhibit intrinsic selection bias: two meta-analyses

Alexis Ogdie, Christopher J. Yarnell, Nadir Yehya, Elizabeth Landzberg et al.
1 citations
Critical Care
Sepsis Diagnosis and Treatment
1.35
article

Observational studies of early versus late salvage therapies in critical care exhibit intrinsic selection bias: two meta-analyses

Alexis Ogdie, Christopher J. Yarnell, Nadir Yehya, Elizabeth Landzberg, Michael O. Harhay
article en
1 citations

Abstract

There were significant differences in the results of observational and experimental studies looking at timing of salvage therapies, partly due to selection bias in observational studies. This issue was worsened by only including subjects who receive the therapy. Randomized trials using objective eligibility criteria remain the best method to determine optimal timing of salvage therapies.

Critical CareVol. 29(1)
University Health Network (CA), Children's Hospital of Philadelphia (US), Emory University (US), University of Toronto (CA), Scarborough Health Network (CA), Children's Healthcare of Atlanta (US), Science History Institute (US), University of Pennsylvania (US)
Openalex Percentile: Top 15%
Sepsis Diagnosis and Treatment
1.35
DOIOpen Access PDFOpenAlex
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Observational studies of early versus late salvage therapies in critical care exhibit intrinsic selection bias: two meta-analyses — Alexis Ogdie, Christopher J. Yarnell, et al. · Critical Care (2025) | TGRS Research Map | TGRS