Predicting lesion reversal in acute cerebral ischaemia via apparent diffusion coefficient threshold on diffusion-weighted MRI
Question Identifying penumbra from permanent ischaemic damage remains challenging, and the role of ADC evaluation before thrombectomy in predicting tissue viability is debated. Findings An ADC threshold of 555 × 10-6 mm²/s yielded moderate sensitivity (73.8%) and low specificity (58.6%) for predicting DWI-R (AUC 0.708). Clinical relevance A uniform ADC threshold has limited utility in identifying salvageable brain tissue in thrombectomy triage. Our findings emphasise the need for caution when excluding acute ischaemic stroke patients from recanalization therapy based on restrictive diffusion.
Authors
- Brian Enriquez (ORCID: https://orcid.org/0000-0002-6535-0445)
- Geir Ringstad (ORCID: https://orcid.org/0000-0003-0919-4510)
- Ingrid Digernes
- Anne Hege Aamodt (ORCID: https://orcid.org/0000-0002-2824-2760)
- Cecilie Mørck Offersen (ORCID: https://orcid.org/0000-0001-5763-6892)
- Kine Mari Bakke (ORCID: https://orcid.org/0000-0003-2127-752X)
- Atle Bjørnerud (ORCID: https://orcid.org/0000-0002-3486-3141)
- Mona K. Beyer
- Terje Nome (ORCID: https://orcid.org/0000-0003-1779-3054)
- Thor Håkon Skattør (ORCID: https://orcid.org/0000-0002-6746-1579)
Institutions
- University of Copenhagen (DK)
- Oslo University Hospital (NO)
- University of Oslo (NO)
- Norwegian University of Science and Technology (NO)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
Publication Details
- Journal
- European Radiology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1007/s00330-025-12014-0
- Citations
- 2
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Universitetet i Oslo